This course is ideal for data scientists, machine learning practitioners, researchers, and graduate students who want to move beyond basic metrics and develop the statistical intuition required for reliable model evaluation in production and research environments.
Understanding how to reliably evaluate machine learning models is essential for building systems that perform well in real-world settings. In this course, you’ll learn modern techniques for assessing classification performance using Receiver Operating Characteristic (ROC) analysis and interpreting key metrics such as Area Under the Curve (AUC) and Concordance Index (C-index).
You’ll also explore a practical framework for supervised learning, focusing on how algorithms select optimal models based on performance measures and how statistical principles support reliable decision-making. The course concludes with a real-world case study using biosignal data, where you’ll apply advanced cross-validation strategies to handle datasets with repeated measurements and ensure unbiased performance estimates.
By the end of the course, you’ll be able to evaluate models rigorously, choose appropriate validation methods, and design machine learning workflows that generalize to new data.
In the first module, we describe how the classification performance of a machine learning model can be estimated using the receiver operating characteristic (ROC). It is explained how the ROC involves calculating model classification performance with multiple different decision thresholds, and how the ROC is a better measure of classification performance than simple classification accuracy or misclassification rate measures. Furthermore, the closely related concepts of an area under the curve (AUC) and the equivalent concordance index (C-index) values are discussed, which summarize the classifier model performance using ROC.
Supplementary material: Calculating C-index in regression case•15 minutes
1 assignment•Total 30 minutes
Classification performance evaluation using receiver operator characteristic•30 minutes
1 discussion prompt•Total 10 minutes
Module 1 Discussion•10 minutes
Case study: Metal ion concentration prediction
Module 2•1 hour to complete
Module details
In this module, an interpretation of supervised machine learning methods simply as abstract mappings from a sample of data to a predictive hypothesis is presented. As an important special case that covers a surprisingly large portion learning algorithms, we consider methods that select an optimal hypothesis based on a given measure of how well hypotheses fit to a sample of data. The measure can be just a straightforward measure of prediction performance of a hypothesis on the sample, such as classification accuracy or regression error. However, it can also be something more complicated and seemingly more distant from the learning objective, such as a function measuring the distance of Voronoi partitions from the sample points as is the case with nearest neighbor methods we consider as example methods. Furthermore, resampling and cross-validation based model selection method considered in the third module are also examples of this framework. The law of large numbers concept is revisited and the so-called bounded differences conditions under which it holds for arbitrary performance measures on a sample of data are considered.
What's included
4 videos1 assignment1 discussion prompt
Show info about module content
4 videos•Total 15 minutes
Introduction to the problem•3 minutes
Metal ion concentration data•4 minutes
Generalizing to new concentrations•5 minutes
Leave-cluster-out for concentration prediction•4 minutes
1 assignment•Total 30 minutes
Case study: Metal ion concentration prediction•30 minutes
1 discussion prompt•Total 10 minutes
Module 2 Discussion•10 minutes
Case study: Pain assessment from biosignal data
Module 3•1 hour to complete
Module details
In this module, a case study on pain assessment from biosignal data is considered in which cross-validation based model performance estimation is conducted with non-independent data sample points. The independence assumption of data samples is violated when data set consists from repeated measurements from the same subject source. Because of these independence violations, the standard leave-one-out cross-validation can not be used, since it leads to biased performance estimation. Instead, with the repeated measurement data a leave-subject-out cross-validation method is utilized, which answers the statistical question on how well the model estimates the experienced pain of new patients not seen in the model training phase.
What's included
4 videos1 assignment1 discussion prompt
Show info about module content
4 videos•Total 41 minutes
Introduction to the problem•7 minutes
Biosignal data and pain assessment case study•9 minutes
Leave-cluster-out for pain assessment•10 minutes
Validation of the pain assessment results•14 minutes
1 assignment•Total 30 minutes
Case study: Pain assessment from biosignal data•30 minutes
28DIGITAL is Europe’s digital innovation engine, a multi-stakeholder platform, rooted in European values and open to the world. We turn knowledge into innovation, scale start-ups into global ventures, and build the next generation of digital talent to shape a fair, competitive, and human-centric digital future.
We work at the intersection of science, business, and society, transforming breakthroughs in AI, cybersecurity, robotics, and advanced computing into solutions that foster digital technology innovation, accelerate the green transition, and improve lives.
28DIGITAL provides online and face-to-face Innovation and Entrepreneurship education to raise quality, increase diversity, and expand the availability of top-level content from 20 leading technical universities across Europe. The universities deliver a unique blend of the best of technical excellence, entrepreneurial skills, and mindset to digital engineers and entrepreneurs at all stages of their careers. The academic partners support Coursera’s bold vision to enable anyone, anywhere, to transform their lives by providing access to the world’s best learning experiences. This means that 28DIGITAL gradually shares parts of its entrepreneurial and academic education programmes to demonstrate its excellence and make it accessible to a much wider audience.
28DIGITAL's online education portfolio can be used in blended education settings, in both Master's and Doctorate programmes, and by professionals to update their knowledge.
When will I have access to the lectures and assignments?
To access the course materials, assignments and to earn a Certificate, you will need to purchase the Certificate experience when you enroll in a course. You can try a Free Trial instead, or apply for Financial Aid. The course may offer 'Full Course, No Certificate' instead. This option lets you see all course materials, submit required assessments, and get a final grade. This also means that you will not be able to purchase a Certificate experience.
What will I get if I subscribe to this Specialization?
When you enroll in the course, you get access to all of the courses in the Specialization, and you earn a certificate when you complete the work. Your electronic Certificate will be added to your Accomplishments page - from there, you can print your Certificate or add it to your LinkedIn profile.
Is financial aid available?
Yes. In select learning programs, you can apply for financial aid or a scholarship if you can’t afford the enrollment fee. If fin aid or scholarship is available for your learning program selection, you’ll find a link to apply on the description page.